ABOUT ME
I am a research scientist in biostatistics/pharmacometrics at the French Institute of Health & Medical Research (Inserm), specialized in infectious diseases and antiviral treatment. My researches have theoretical objectives, such as developing mathematical models to understand quantitative aspects of host/pathogen interaction. They also aim to impact clinical research by optimizing drug combination, dosing regimen and identify characteristics associated with a differential response to antiviral treatment.
My researches have initially focused on chronic viral infections (HIV, HBV, HCV) and have progressively shifted to acute emerging viral infections (SARS-CoV-2, viral hemorrhagic fever). I also apply the models and the statistical methods developed in virus dynamics to other fields of research, in particular bacterial dynamics (microbiota, phage therapy) and cancer.
I work in the IAME laboratory devoted to infectious diseases, and located on the premises of Hospital Bichat campus, in the north of Paris. Together with Pr France Mentré, I am co-leading a group of pharmacometrics, biostatistics and clinical investigation in infectious diseases of about 30 young scientists (Master & PhD students, Postdocs) and tenured scientists.
EDUCATION/CURRICULUM
CURRENT GROUP
Modeling the impact of antiviral treatments in SARS-CoV-2 infected individuals
PhD thesis of Aurélien Marc, funded by Bill & Melinda Gates fundation
2012
Chargé de recherche (Research Scientist)
INSERM / Université Paris Cité
Monkeypox infection and modeling
Postdoc Bach Nguyen, funded by ANRS
Development of a modeling framework to optimize combination therapy of new antiviral agents against Hepatitis B virus.
PhD thesis of Selma El Messaoudi, in collaboration with Annabelle Lemenuel-Diot, funded by Roche pharmaceuticals
2007 - 2009
Postdoctoral fellow
Bar-Ilan University (Tel-Aviv, Israel)
Director: Prof Avidan U. Neumann
2003 - 2006
PhD thesis
Université Bordeaux 2
Director: Daniel Commenges & Rodolphe Thiébaut
2000 - 2003
Ecole Nationale de la Statistique & de l'Analyse de l'Information (ENSAI)
2009 - 2012
Postdoctoral fellow
Los Alamos National Laboratory (New Mexico, USA)
Director: Alan S Perelson
Modeling the impact of antiviral treatment at the individual and populational levels
Postdoc of Hind Zaaraoui, in collaboration with Lulla Opatowski, funded by Orchestra (EU H2020)
2021
Directeur de recherche (Research Director)
INSERM / Université Paris Cité
Repurposed drug therapy in emerging viral diseases
Postdoc Guillaume Lingas, funded by Ecole de Recherche de l'INSERM
Modeling the efficacy of antiviral strategies against variants of concerns of Sars-CoV-2: from general community to hospitalized patients
PhD thesis of Maxime Beaulieu, funded by Université Paris Cité (Contrat Doctoral)
Interactions in gut flora during antibiotic treatment
Postdoc of Carlos Olivares, cosupervised with Charles Burdet, funded by ANR Bla Impact